Increasing Temperature Accelerates Protein Unfolding Without Changing the Pathway of Unfolding
نویسندگان
چکیده
منابع مشابه
Increasing temperature accelerates protein unfolding without changing the pathway of unfolding.
We have traditionally relied on extremely elevated temperatures (498K, 225 degrees C) to investigate the unfolding process of proteins within the timescale available to molecular dynamics simulations with explicit solvent. However, recent advances in computer hardware have allowed us to extend our thermal denaturation studies to much lower temperatures. Here we describe the results of simulatio...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2002
ISSN: 0022-2836
DOI: 10.1016/s0022-2836(02)00672-1